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About 5× higher lifetime risk of breast and ovarian cancer.BRCA1 normally helps repair damaged DNA. A harmful variant raises the lifetime risk of breast and ovarian cancer well above average, which is why carriers benefit from earlier and more frequent screening.CancerDisease riskBRCA1
Raised risk of breast, ovarian, prostate and pancreatic cancers.Like BRCA1, BRCA2 is a DNA-repair gene. Variants increase the risk of several cancers in both women and men, so screening and risk-reducing options are worth discussing with a clinician.CancerDisease riskBRCA2
Lynch syndrome: sharply higher risk of colorectal and several other cancers.MLH1 is one of the main genes behind Lynch syndrome. Harmful variants raise the lifetime risk of colorectal cancer and several other cancers, which is why earlier colonoscopy and coordinated screening can matter a lot if you carry one.CancerDisease riskMLH1

Educational reference only. Not a diagnosis. Discuss significant findings with a clinician.