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Gene Explorer / MLH1

MLH1

Disease riskCancerStrong evidenceHigh attention

Lynch syndrome: sharply higher risk of colorectal and several other cancers.

MLH1 is one of the main genes behind Lynch syndrome. Harmful variants raise the lifetime risk of colorectal cancer and several other cancers, which is why earlier colonoscopy and coordinated screening can matter a lot if you carry one.

Also known as: Lynch syndrome, HNPCC

Associated with

  • lynch syndrome
  • colorectal cancer
  • colon cancer
  • hereditary cancer

Educational only. Significant findings should be reviewed with a clinician.

More Cancer genes

Educational reference only — not a diagnosis. Discuss significant findings with a clinician.